ACE-031 1mg

ACE‑031 — Research Product Description (Compliant, Professional, Non‑Medical)

Overview

ACE‑031 is a recombinant fusion protein designed for laboratory investigation of myostatin pathway modulation. It combines the extracellular domain of the human activin receptor type IIB (ActRIIB) with a human IgG1‑Fc fragment, creating a soluble receptor analog that can bind select ligands within the TGF‑β superfamily. This structure makes ACE‑031 a valuable tool for studying muscle biology, growth factor signaling, and ligand–receptor interactions in controlled research environments.

Key Research Characteristics

• Type: Recombinant ActRIIB‑Fc fusion protein
• Primary Research Focus: Myostatin/activin pathway interactions
• Format: Lyophilized powder
• Purity: ≥ 95% (HPLC)
• Molecular Weight: ~100 kDa (dimeric form)
• Storage Conditions: −20°C (long‑term), protect from repeated freeze–thaw cycles
• Solubility: Water‑soluble; reconstitution recommended with sterile aqueous buffer

Research Applications

ACE‑031 is commonly used in laboratory settings to explore:

• Ligand binding dynamics within the ActRIIB signaling axis
• Myostatin pathway inhibition models
• Muscle cell differentiation and growth factor signaling
• Receptor–ligand competition assays
• TGF‑β superfamily interactions

These applications are strictly for in vitro or controlled experimental environments.

Handling & Reconstitution

• Allow vial to reach room temperature before opening
• Reconstitute with sterile water or buffer to desired concentration
• Gently swirl—do not vortex
• Aliquot after reconstitution to avoid degradation from freeze–thaw cycles