Dihexa 10mg Research Compound

Product Overview

Dihexa, also known as PNB-0408 or N-hexanoyl-Tyr-Ile-(6)-aminohexanamide, is a synthetic peptide-derived research compound based on angiotensin IV analog chemistry. It has been investigated in laboratory models involving neuronal signaling, dendritic-spine formation, synaptic connectivity, hepatocyte growth factor (HGF), and the MET receptor pathway.

Northwest Peptides supplies Dihexa 10mg as a premium-quality research compound manufactured exclusively for laboratory research purposes. Every batch undergoes analytical verification and includes a batch-specific Certificate of Analysis (COA).

Research Overview

Dihexa was developed as a metabolically stabilized, lipophilic analog derived from earlier angiotensin IV research compounds. Preclinical investigations have examined Dihexa in cellular and animal models related to synaptic signaling, dendritic-spine formation, spatial-learning tasks, neuronal connectivity, and HGF/MET-pathway activity.

Published studies proposed that Dihexa could interact with HGF and influence signaling through its receptor, MET. However, several foundational publications supporting this proposed mechanism were retracted in 2025 following findings of unreliable or falsified data. These retractions substantially limit confidence in the original mechanistic claims.

Dihexa remains an experimental compound. It has not been established as safe or effective in humans and is not an FDA-approved treatment for Alzheimer’s disease, Parkinson’s disease, cognitive impairment, or any other condition.

Quick Facts

Quality Assurance

Every batch of Dihexa undergoes strict quality verification before release.

• ≥99% Purity Verified by HPLC
• Batch-Specific Certificate of Analysis (COA)
• Identity Verification
• Lyophilized for Long-Term Stability
• Secure Laboratory Packaging
• Manufactured for Research Applications Only

Research Applications

Published preclinical literature has investigated Dihexa in:

• Angiotensin IV analog research
• HGF/MET signaling studies
• Dendritic-spine research
• Synaptic-connectivity models
• Neuronal-cell signaling
• Hippocampal cellular models
• Spatial-learning animal models
• Small-molecule neurobiology
• Hepatocyte-differentiation research

Literature Summary

Dihexa is a metabolically stabilized angiotensin IV analog designed to improve upon the stability and physicochemical characteristics of earlier experimental compounds. Early rodent and cellular studies reported associations with dendritic-spine formation, synaptic markers, and performance in spatial-learning models.

Researchers proposed that these observations involved interaction with HGF and subsequent MET-receptor signaling. Some studies also examined Dihexa in cellular-differentiation and sensory-cell models involving the HGF/MET pathway.

The evidence requires substantial caution. Three papers from the originating research group—including a frequently cited 2014 Dihexa mechanism paper—were retracted in 2025 after an institutional investigation identified falsified or fabricated data. An additional primary characterization paper received an expression of concern.

Consequently, the proposed HGF/MET mechanism and reported cognitive findings should be regarded as unconfirmed. Controlled human safety and efficacy data are not available.

Related Research Compounds

Researchers investigating neuronal signaling and experimental peptide biology frequently explore:

• Semax
• N-Acetyl Selank
• Pinealon
• Humanin
• SS-31
• Epitalon

Frequently Asked Questions

What is Dihexa?

Dihexa is a synthetic peptide-derived angiotensin IV analog investigated in preclinical models involving neuronal signaling, dendritic-spine formation, synaptic biology, and the HGF/MET pathway.

Is Dihexa a conventional peptide?

Not exactly. Dihexa is generally classified as a peptide-derived small research compound or metabolically stabilized angiotensin IV analog rather than a conventional research peptide.

Has Dihexa been studied in humans?

No reliable controlled human safety or efficacy studies have established Dihexa as safe or effective for any medical purpose.

Is Dihexa an approved treatment for Alzheimer’s disease?

No. Dihexa is not approved by the FDA to diagnose, treat, cure, or prevent Alzheimer’s disease, Parkinson’s disease, cognitive impairment, or any other condition.

Have any Dihexa studies been retracted?

Yes. Several foundational publications concerning angiotensin IV analogs and the proposed HGF/MET mechanism were retracted in 2025. This significantly limits confidence in the original findings.

Who may purchase Dihexa?

Northwest Peptides supplies Dihexa exclusively for lawful laboratory research.

How is it supplied?

Each vial contains 10mg of high-purity lyophilized Dihexa.

Does every batch include a COA?

Yes.

How should it be stored?

Store lyophilized material at approximately -20°C in a dry environment.

How quickly are orders shipped?

Orders are typically processed within one business day.

References

Representative research and notices include:

• McCoy AT, et al. Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents. Journal of Pharmacology and Experimental Therapeutics. 2013. Subsequently subject to an expression of concern.
• Benoist CC, et al. The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-Met system. Journal of Pharmacology and Experimental Therapeutics. 2014. Retracted in 2025.
• Kawas LH, et al. Development of angiotensin IV analogs as hepatocyte growth factor/Met modifiers. Journal of Pharmacology and Experimental Therapeutics. 2012. Retracted in 2025.
• Siller R, et al. Small-molecule-driven hepatocyte differentiation of human pluripotent stem cells. Stem Cell Reports. 2015.
• Beedie SL, et al. Hepatocyte growth factor mimetic protects lateral-line hair cells from aminoglycoside exposure. Frontiers in Cellular Neuroscience. 2015.

Research Use Disclaimer

This product is intended strictly for lawful laboratory research purposes only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent Alzheimer’s disease, Parkinson’s disease, cognitive impairment, or any other disease. This product has not been evaluated or approved by the U.S. Food and Drug Administration.

Call to Action

Order premium-quality Dihexa 10mg from Northwest Peptides. Every batch is independently COA verified and HPLC tested for qualified laboratory research.